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Freddie Martin

Freddie Martin

Postdoc

NNF Center for Protein Research | Stroud, UK

Technologies

My Portfolio Highlights

My New Project

Exploring NYC Public School Test Result Scores

My New Project

Exploring NYC Public School Test Result Scores

Looking to explore the intersection of AI and biology.

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

Courses

Joining Data with pandas
Exploratory Data Analysis in Python
Introduction to Data Visualization with Seaborn
Python Toolbox

My Work Experience

Where I've interned and worked during my career.

Copenhagen | Oct 2022 - Present

Postdoctoral Research Associate

In the Taylor group, I am using protein design, AI, and molecular biology to study molecular machines and the interactions between bacteria and bacteriophages. During this time I have also written several grant applications, both for myself and in collaboration with other group members to secure future funding, and seperately, time at external CryoEM facilities. I also have been involved in organising our 2023 group retreat, including running a protein design workshop and the upcoming 2023 NNF CPR Symposium.
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University of Bristol | Jun 2022 - Sep 2022

Postdoctoral Research Associate

N/A

University of Bristol | Oct 2017 - Jun 2022

PHD Candidate

PhD Supervisor: Prof. Dek Woolfson Thesis title: Exploring the Dynamic and Conformational Landscape of α-Helical Peptide Assemblies Overview: Using rational and computational approaches I aimed to understand the sequence-to-structure relationships that dictate the final fold and dynamic properties of α-helical coiled coils, in order to facilitate the design of new and improved assemblies. During this time, I have had the opportunity to learn many new skills, work collaboratively on several projects, and supervise master’s students doing research projects in the lab. Further, I have worked with others to secure time at DLS and ESRF synchrotrons for solution-phase, and crystal x-ray diffraction experiments. Experience: • Solid-phase peptide synthesis, protein extraction, and purification. • In vitro biophysical characterisation of proteins through circular dichroism, analytical ultracentrifugation, size-exclusion chromatography, and fluorescence-based assays. • Structural analysis by x-ray diffraction of protein crystals, transition electron microscopy, and small-angle x-ray scattering. • Computational design, analysis, and evaluation of individual proteins, protein- protein, and protein-ligand interactions in silico. Using packages including ISAMBARD, AMBER, AUTODOCK, and Rosetta. • Use and development of protein structure prediction software including AlphaFold2, RoseTTAFold, and ab initio methods. Rotation Student, University of Bristol, Chemical Synthesis CDT 2017-2018 During the first year at the CDT, I carried out three 8-week rotation projects, alongside other courses. One of the rotations was in the Woolfson lab, omitted as it became one of my projects during my PhD. Supervisors: Prof. Ian Manners, Prof. Carmen Galan Project overview: Investigating the for the delivery of therapeutics. Experience: • Self-assembly of block co-polymers • Air-sensitive, glove-box chemistry • Transition electron microscopy • Synthesis of sugar derivatives

Spin Up Science | Jul 2020 - Jul 2020

Trainee Consultant

Training programme as delivered by the Spin Up Science team. Developed and delivered a comprehensive plan including market research and strategy for a start-up company.

GSK | Sep 2015 - Aug 2016

Industral Placement Student

I worked in the Bioanalytical Sciences and Toxicokinetics (BST) subdivision of the Drug Metabolism and Pharmacokinetics (DMPK) department. My Roles included (from the official job description): -Routine analysis of drug and metabolites in biological and formulation media to preclinical and trial standards using defined analytical methods. -Development and validation of analytical methods for the characterisation and measurement of drug metabolites in biological matrices. -Maintenance and use of analytical instrumentation for sample identification and quantification purposes. -Ensure work is conducted in compliance with the relevant GLP regulations. -Follow safe working practices and be responsible for the health and safety of themselves and others.

My Education

Take a look at my formal education

PhD - Protein Design in Chemical BiologyUniversity of Bristol | 2022
Master’s Degree, Chemistry for Drug Discovery with Industrial TrainingUniversity of Bath | 2017

About Me

Freddie Martin

My passion is to use advances in AI and rational understanding of atomic interactions to develop new knowledge, tools, and therapies.

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