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christa toenhake

christa toenhake

Scientist

Arbo Unie BV | Netherlands

Technologies

My Portfolio Highlights

My New Project

Analyzing Unicorn Companies

My New Course

Introduction to SQL

My New Track

SQL Fundamentals

My New Project

Analyzing Unicorn Companies

Insightful puzzle solver, piecing together data fragments to reveal the big picture.

My Work

Take a look at my latest work.

course

Introduction to SQL

course

Intermediate SQL

course

Joining Data in SQL

course

Introduction to SQL

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

Courses

Introduction to SQL
Intermediate SQL
Joining Data in SQL
Supervised Learning with scikit-learn

My Work Experience

Where I've interned and worked during my career.

Genova Genomic Research Center | Mar 2021 - Sep 2022

Biomedical Data Scientist

In this position I work as a biomedical data analist and data scientist in the data science team at Genova Genomic Research Center. In this team we use data mining and machine learning algorithms to solve medical classification problems (e.g., DNA methylation-based discrimination between primary cancer and cancer free patients), and we bring the Genomic-ID software platform to a higher TRL level. My responsibilities include exploratory data analysis and reporting (working with SQL, rmarkdown, bookdown); post-mining analysis of (methylation) biomarkers (DESeq2, GenomicRegions, statistical enrichment analysis, GSEA); development of machine learning modules (scikit-learn, logistic regression, random forest etc); and conversion of scripts to version released R and Python packages hosted on the company’s Git service for incorporation in the software platform (Linux environment). I also contribute input to the software design plan, keep an eye on our deadlines and present progress to the rest of the company. I am an advocate for teamwork and to enhance collaboration in our team I set up a book club, stimulate code reviews, and am actively structuring our use of tools for planning and documentation.
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Faculty of Science (Radboud University Nijmegen) | Sep 2020 - Mar 2021

Medewerker onderwijsontwikkeling

In this position, I (co)developed new course material for the courses Functional Genomics (interactive learnr tutorial on ChIP-seq analysis, R, GenomicRegions, heatmaps, clustering, chromHMM, FAIR data) and Advanced Molecular Biology (H5P tutorial on the interpretation of WB, qPCR, sanger sequencing etc).

Radboud University | Jun 2019 - Jun 2020

Postdoctoraal onderzoeker

In this project, I set up single-cell transcriptomics and analysis for malaria- infected hepatocytes to study factors and pathways involved in dormancy (CEL-seq2 platform, trim_galore, fastp, UMI-tools, STAR, Seurat, scater, clustree, ComplexHeatmap, diffbind etc). Dormancy is a phenotype found in several malaria species that is hypothesized to be responsible for malaria relapses. (publication in progress)

Radboud University | Mar 2014 - Aug 2018

Promovendus

Ik doe onderzoek naar de regulatie van genexpressie in de malaria parasiet met behulp van verschillende genomics technieken (ChIP-seq, ATAC-seq, RNA-seq en quantitative proteomics) en bijbehorende data analyse in R en bash scripts. • Onderzoeken opzetten, analyseren, presenteren en publiceren • Master- en bachelorstudenten begeleiden

University of Glasgow | Jul 2012 - Jul 2013

Student Researcher

During this one-year internship in the lab of Prof. Andy Waters, I studied the role of two ALBA proteins in the rodent malaria parasite Plasmodium berghei. To this end I used traditional cloning and gene modification techniques, performed western blotting, immunofluerescence microscopy (IFA) and electrophoretic mobility shift assays (EMSAs). All of these experiments I performed with the the great supervision of Dr. Nisha Philip.

Leiden University Medical Center | Feb 2011 - Aug 2011

Student Researcher

5-month research project in the lab of Prof. Tom Ottenhoff studying biomarker identification and inhibition of MHC class II antigen presentation in the context of tuberculosis infection under the supervision of Dr. Marielle Haks. Techniques: Cell culture; fow cytometry; RNA isolation and expression measurements; siRNA gene silencing.

Leiden University Medical Center | Mar 2010 - Jul 2010

Student Researcher

12-week research project in the lab of Prof. Maria Yazdanbakhsh. With the supervision of Linda Wammes I studied regulatory T cells in asymptomatic malaria infection by flow cytometry.

My Education

Take a look at my formal education

MSc Biomedical Sciences, ResearchUniversiteit Leiden | 2014
BSc, Biomedische WetenchappenUniversiteit Leiden | 2010

About Me

christa toenhake

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