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Gianluca Moretti

Bioinformatics Scientist in Takura AB, Head of R&D and Production in Cellavos AB

Takura AB

Technologies

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

My Work Experience

Where I've interned and worked during my career.

Takura AB | Jul 2022 - Present

Bionformatics and computational biology scientist

Implementation of the workflow and internal pipeline for single cell sequencing analysis. Collaboration and training with the Single cell sequencing facility of Karolinska Institutet.

Takura AB | Jan 2021 - Jul 2022

Head of Process Development

Support for the construction of the proprietary GMP cell factory of the group with focus on selection of the equipment. Training of the GMP manufacturing staff on the cell production process for an IND based on human MSCs. Coordination of experiments for improvement of the manufacturing process.

Shoaie group, System biology Division, KTH | Sep 2021 - Feb 2022

Master Thesis Project

Thesis title: “Optimizing the use of the software Pairwise Comparative Modelling (PCM) for prediction of antimicrobial resistance determinants in human stool derived microbiome data.” Analysis of the computational resource’s usage for the Nextflow based software PCM. Development of a new version of PCM that allowed a more flexible allocation of the resources. Validation of the new version of the software using soil derived metagenomic sequences and benchmarking against the original version of the software. Assembly and gene prediction of the metagenomic sequences derived from human stool and saliva samples. Application of the software to this dataset.

Cellavos AB, subsidiary of Takura AB | Jan 2019 - Present

Head of Product Development and Production

Responsible for the transition toward GMP compliant manufacturing. Development of a second cell based IND based on a different tissue source. Development of a third IND based on extracellular vesicles/exosomes. Assays development. Establishment of a collaboration with the Veterinary University of Perugia. Budgeting responsibilities. Regulatory affair activities together with external consultants. Facility management. Strategical planning together with the CEO of the company. Participation in the Board meetings. Business development through negotiation of partnership with other companies of the field. Consulting activities for the sister companies of the TAKURA AB group.

Cellavos AB, subsidiary of Takura AB | Aug 2017 - Jan 2019

Production Manager

Successful scale up of the production with around 300 horses treated with our IND in 1-year time in a preclinical setting.

Cellavos AB, subsidiary of Takura AB | Mar 2017 - Aug 2017

Production Technician

From idea to a pre-clinical cell-based therapy to be used for orthopaedic injuries in horses. Set up of the laboratory and optimisation of the production methodology. Implementation of existing SOPs. Assets purchase and management. Executing 100% of the activities for the manufacturing process. Successful production of hundreds of doses of the IND.

Karolinska institutet | Sep 2016 - Mar 2017

Research Assistant

Design and run in vivo and in vitro experiment with human or mouse cells. Write reports of the experiments. Take care of ordering of lab consumables and new equipment.

Karolinska institutet | Oct 2015 - Aug 2016

Research Trainee

Design and run in vivo and in vitro experiment with human or mouse cells.

Karolinska institutet | Jun 2015 - Sep 2015

Erasmus Traineeship in the Olle Ringden group, Lab Med Department

Long-term effects of placenta-derived decidual stromal cells on immune reconstitution after allogenic hematopoietic stem cell transplantation.

University of Perugia | Mar 2014 - May 2015

Master Thesis and traineeship

In vivo experiment on mice model of fungal infection. Use of different molecular biology and immunological analytical techniques, such as ELISA, nucleic acid extraction, qPCR, genotyping of mice. Emphasis on the study of gene expression with GeneChip Expression Profiling Arrays.

Laboratory of Pharmacology, Department of Experimental Medicine, | Dec 2011 - May 2012

Bachelor thesis

N/A

My Education

Take a look at my formal education

Master of Science Bioinformatics in BioinformaticsUniversity of Skövde | 2022

Master of Science in Pharmaceutical Biotechnology in immunology, pharmacology, pharmaceutical chemistryUniversity of Perugia | 2015

Bachelor of Science in Biotechnology in molecular biology, system biology, chemistry, geneticsUniversity of Perugia | 2012

About Me

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