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Helene Damhofer

Helene Damhofer

Certified

Senior Scientist

BiOrigin | Copenhagen

Technologies

My Portfolio Highlights

My New Course

Introduction to R

My New Course

Introduction to R

Data explorer, embarking on expeditions to uncover hidden insights.

My Work

Take a look at my latest work.

course

Introduction to the Tidyverse

course

Introduction to R

course

Intermediate R

course

Introduction to the Tidyverse

My Certifications

These are the industry credentials that I’ve earned.

AI Fundamentals

AI Fundamentals

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

Courses

Introduction to Python
Introduction to R
Understanding Prompt Engineering
Intermediate Python

My Work Experience

Where I've interned and worked during my career.

BiOrigin | Jun 2023 - Present

Senior Scientist

• Evaluated incoming scientific assets across diverse therapeutic areas (oncology, inflammation, neurodegeneration), providing assessment of scientific robustness, key risks and translational potential • Designed and executed experimental studies to validate novel technology platforms and therapeutic modalities on behalf of the Novo Holdings Seed Investment Team • Led and completed two wet-lab due diligence projects, delivering conclusive data directly informing investment decisions • Managed collaborative projects with Novo Seeds portfolio companies, contributing to the development of critical assays and reagents for drug discovery programs • Conducted scouting activities through literature reviews, conference participation, and seminars to identify innovative assets for in-licensing, internal incubation, or biotech company formation • Incubated an internal project for a novel first-in-class oncology drug target; designed and performed proof-of-concept biological studies to validate target biology and tumor selectivity • Collaborated closely with cross-functional scientific teams (incl. CROs) on a range of internal and external drug discovery projects, fostering innovation and knowledge exchange
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The Institute of Cancer Research | Sep 2021 - May 2023

Staff Scientist

• Designed and executed pooled whole-genome CRISPR knock-out screens to identify novel modulators of androgen receptor therapy in prostate cancer in collaboration with the Translational Therapeutics Team • Lead for scientific operations and management during and after lab relocation from New York to London • Collaborated with scientists in the lab and institute to drive the progress of diverse oncology research projects • Managed, supervised, and trained a junior research technician

Memorial Sloan Kettering Cancer Center | Oct 2018 - Aug 2021

Postdoctoral Research Fellow

Dr. Kristian Helin Lab @ Rockefeller Research Laboratories (MSKCC) • Validated and characterized therapeutic targets in glioma stem cells, including kinase MAP3K7 and chromatin-binding proteins PHF23 and ING3, through mechanistic studies • Developed multiple CRISPR/Cas9 knock-out and knock-in models in human and mouse glioma systems and embryonic stem cells, incorporating epitope and degron tags for biological studies • Introduced FKBP12 F36V (dTAG) knock-in degron tag technology to the lab for mechanistic studies and target validation, resulting in a peer-reviewed publication in STAR Protocols • Presented research findings regularly at lab meetings and biannual departmental seminars at Memorial Sloan Kettering Cancer Center • Collaborated on uncovering complex-dependent roles of KAT8 in transcription and cellular homeostasis, contributing to a publication in Molecular Cell • Partnered with computational biologists to analyze gene expression and chromatin-binding data, driving innovative discoveries and advancing project milestones • Established cross-lab collaborations, including ChIP-seq studies with Christine Mayr (MSKCC) and kinase inhibitor characterization with Timothy Haystead (Duke University) • Maintained rigorous documentation of experimental workflows and results in electronic lab notebooks to ensure reproducibility and compliance • Managed, supervised, and trained a senior research technician at MSKCC laboratory • Supervised rotation student (PhD fellow) from Weill Cornell Medicine Graduate School of Medical Sciences program

Biotech Research and Innovation Centre (BRIC), University of Copenhagen | Sep 2015 - Dec 2019

Postdoctoral Researcher

Laboratory of Kristian Helin (Institute Director) • Executed pooled CRISPR knock-out and interference screens to identify novel vulnerabilities in patient-derived glioma stem cells, advancing therapeutic target discovery • Validated genetic screen hits (RNAi and CRISPR) in murine and human glioma stem cell models through loss-of-function and mechanistic studies to assess therapeutic potential • Collaborated on uncovering PRC2-mediated H3K27me3 deposition in mouse embryonic stem cells, contributing to a publication in Nature Structural & Molecular Biology • Established strategic collaborations with Uppsala University and Steven Pollard’s lab (University of Edinburgh) to expand the panel of primary human glioma stem cell lines, forming the foundation for ongoing glioma research projects • Presented research findings regularly at group and institutional meetings to communicate progress and foster scientific exchange • Secured competitive funding, writing successful grant applications and receiving a 3-year postdoctoral fellowship from the Danish Cancer Society

Academic Medical Center (AMC) | Nov 2010 - Apr 2015

PhD candidate

Laboratory of Prof. Jan Paul Medema, Co-Supervised by Dr. Maarten Bijlsma • Identified key stromal factors in the pancreatic tumor microenvironment and demonstrated enhanced signaling upon Hedgehog ligand blockade, contributing to publications in Journal of Cell Science and Molecular Oncology • Developed a novel high-content microscopy assay (Operetta) to quantify Hedgehog signal propagation, instrumental for findings published in the Journal of Cell Science • Established patient-derived cell line and organoid models, as well as xenografts from pancreatic cancer surgical specimens, supporting translational research published in the Journal of Translational Medicine • Created 3D co-culture models to study pancreatic tumor–stroma interactions and therapeutic response • Pioneered the setup and expansion of BioPAN, a blood and tissue biobank for pancreatic carcinoma patients, collaborating with a multidisciplinary team of surgeons, clinicians, and scientists • Discovered ADAM12 as a predictive biomarker for stromal activation and therapy response, in collaboration with Celgene, published in Oncogenesis • Wrote and published 3 first-author and contributed to 4 second-author papers in peer-reviewed journals

My Education

Take a look at my formal education

Doctor of Philosophy (Ph.D.), MedicineUniversity of Amsterdam | 2015
Master of Science (MSc), GeneticsUniversität Salzburg | 2010
Bachelor of Science (BS), GeneticsUniversität Salzburg | 2008
High School Bundesbildungsanstalt für Kindergartenpädagogik (BAKIP) Steyr | 2005

About Me

Helene Damhofer

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