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James Klimavicz

James Klimavicz

Senior Data Scientist

TetraScience | North Carolina

Technologies

Scientific data expert, analyzing chemical and biochemical data for pharmaceutical research

My Work

Take a look at my latest work.

course

Understanding Artificial Intelligence

course

Understanding Artificial Intelligence

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

Courses

Understanding Artificial Intelligence
Understanding ChatGPT
Introduction to Deep Learning with PyTorch
Introduction to Snowflake SQL

My Work Experience

Where I've interned and worked during my career.

TetraScience | Feb 2022 - Present

Scentific Data Architect III

Assess customer scientific use cases, data workflows, and data integration needs. Propose architectural diagrams for improved data workflows. Develop and update vendor-agnostic schema for harmonized data ingestion. Serve as scientific subject matter expert in chromatography. Work with customer data scientists to improve data querying from the TetraScience data platform databases using SQL and ElasticSearch via APIs. Create python scripts for internal and external-facing tools for accessing and reducing data, and updating data labels and metadata.
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Envance Technologies | Aug 2020 - Feb 2022

Director of Discovery and Innovation

Project leader for the development, synthesis, and assaying of biologically active small molecules with novel modes of action. High-throughput virtual screening of ligand-protein interactions of small molecules for lead compound identification and optimization. Development of GCMS methods for qualitative and quantitative analysis of powder-, water-, and oil- based formulations. Whole-organism bioassay development for mode of action and efficacy studies and dose-response analysis. Formulation development of consumer pest control products with a focus on efficacy and safety to the user. Collaboration with industry partners on product specifications and requirements.

Envance Technologies | Feb 2020 - Aug 2020

Discovery and Innovation Scientist

Monoterpenoid/Phenylpropanoid containing compounds and methods of their making and use as herbicides. Monoterpenoid/Phenylpropanoid containing compounds and methods of their making and use as seed treatments Compounds and compositions for nematode treatment.

Iowa State University | Sep 2017 - Aug 2020

Graduate Student

PhD Student in Toxicology and Chemistry Graduate Minors in Entomology and Statistics Preparation, purification, and characterization of more than 400 heterocyclic small molecules and synthetic terpenoid analogs for screening for pesticidal activity. Development of (quantitative) structure-activity relationship models and analysis of dose-response data. Exploration of 30+ novel non-volatile terpenoid-based insecticides for insect baits and seed treatments/coatings and isolation and purification of natural terpenoids from crude extracts and natural oils. Whole-organism in vitro bioassays of biorational pesticides using fungal and bacterial cultures and C. elegans. Substantial interaction with industry partners.

University of Cambridge | Sep 2016 - Aug 2017

Graduate Student

MPhil in Scientific Computing, Darwin College Exploration of stable conformers and molecular dynamics evaluation of small DNA sequences implicated in genetic diseases and microbiological pathogenesis. Development, implementation, and integration of high-performance computing algorithms written in Fortran 90 into computational chemistry packages for deployment.

Iowa State University | Aug 2014 - Sep 2016

Research Chemist

Preparation and characterization of synthetic terpenoids for screening for insecticidal activity and insect repellency. Projects include: • Fluorination and functional group transformations of sequiterpenoids • Development of terpenoid-based additives for insect-control baits • Isolation and purification of natural terpenoids from crude extracts and natural oils

National Institutes of Health | May 2014 - Aug 2014

Intramural Research Fellow

Development and optimization of antibody assays to detect disease using human sera. Projects included: • Searching for novel antibodies in sera for specific diseases, such as tuberculosis and Sjögren’s Syndrome, an autoimmune disease • Synthesis of antibody-luciferase chimera proteins via plasmid ligation for light-based immunoprecipitation studies • Development of high-throughput sera assays to detect potential for disease formation prior to clinically significant symptoms • Statistical analysis of RNA-Seq data to discover trends using mathematic modeling

My Education

Take a look at my formal education

Doctor of Philosophy - PhD, Organic Chemistry and ToxicologyIowa State University | 2020
Master of Philosophy - MPhil, Scientific ComputingUniversity of Cambridge | 2017
Bachelor’s Degree, MathematicsIowa State University | 2016
Master's Degree, Organic ChemistryIowa State University | 2013
Bachelor's Degree, ChemistryIowa State University | 2011

About Me

James Klimavicz

Chemistry and biochemistry data specialist with experience in pharmaceuticals and agrochemicals. Open to new opportunities.

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