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Sébastien Wieckowski

Sébastien Wieckowski

Scientist, Immuno-oncologist, PhD

second scight | France

Technologies

My Portfolio Highlights

My New Track

SQL Fundamentals

My New Course

Introduction to Python

My New Track

SQL Fundamentals

Champion of data ethics, navigating the fine line between insights and privacy.

My Work

Take a look at my latest work.

course

Introduction to R

course

Introduction to Python

course

Intermediate Python

course

Introduction to R

DataCamp Course Completion

Take a look at all the courses I’ve completed on DataCamp.

Courses

Introduction to Python
Introduction to R
Intermediate Python
Data Manipulation with pandas

My Work Experience

Where I've interned and worked during my career.

second scight | Apr 2023 - Present

Biotech R&D and Data Expert

second scight empowers biotech and pharma companies with comprehensive data consulting services to accelerate drug development, optimize clinical trials, and improve patient outcomes. Whether you want to analyze your data from a different angle, obtain a thorough, critical and unbiased evaluation, or make your project shine a little more, let's work together to get you a second scientific sight! https://secondscight.com
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百明信康生物技术（杭州）有限公司 Worgpharma | Nov 2021 - Feb 2023

Director Nonclinical Development

▪ development of the preclinical program for our drug candidates ▪ in vitro and in vivo pharmacology, pharmacokinetics and toxicology ▪ IND-enabling GLP program from scratch for a small molecule in ophthalmology ▪ extension of non-clinical package for supporting a Phase 2a clinical trial ▪ EMA, FDA and CDE (China) regulatory documents: pre-IND Briefing Package, Investigator Brochure, CTD (Module 2.4), IND application ▪ management of all the preclinical operations with CROs GLP | pharmacology | toxicology | nonclinical | PK/PD | ocular toxicity | juvenile toxicology | DART | nonhuman primates | ICH guidelines | FDA | EMA | CDE (China) | IND | CTD | PIND | Graves' Disease | allergy | small molecules | peptides

Roche | Dec 2018 - Oct 2021

Principal Scientist

▪ development of innovative bioassays in immunology and cell and gene therapy (GMP) ▪ training of the technical staff in flow cytometry, and human cell biology/ immunology ▪ scientific and technical support in many projects GMP | ddPCR | imaging cytometry | multiplex | RNAseq | NK cells | macrophages | ADCC | ADCP | gene therapy | AAV | Pentraxin-2 | gantenerumab | pertuzumab | glofitamab

Vaximm AG | Oct 2020 - Sep 2021

Senior Scientist (part-time consulting)

▪ responsible for the personalized neoantigen vaccine assembly for the clinical trial NECVAXNEO1 personalised medicine | DNA vaccine | glioblastoma | NGS | neoantigen discovery | epitope assembly | machine learning

Vaximm AG | Feb 2016 - Nov 2018

Senior Scientist

▪ R&D and nonclinical development of the company’s oral T cell vaccine pipeline – VXM01, VXM04, VXM06, VXM10 and VXMNeo ▪ supervision of the immunomonitoring and histopathology GCLP analyses of our phase I/II clinical trials ▪ Business Development (industry, academic collaborations) and interaction with CRO partners ▪ regular and active participation to our Company Board and internal meetings + international congresses DNA vaccine | preclinical | toxicology | angiogenesis | CROs | histology | bioinformatics | data science | business development | Investigator Brochure

Roche | Jan 2012 - Jan 2015

Roche Postdoc Fellowship

▪ assessment of novel tumor stroma-targeted IL-2-variant immunocytokines developped by Roche Glycart (mentor Dr. C. Klein), combined with ▪ anti- cancer therapeutics and immunomodulatory antibodies, in genetically engineered mouse models of non-small cell lung cancer ▪ collaborations with Prof. Dario Neri (ETHZ), Prof. M. Pittet (MGH), CureVac ▪ deputy study director for animal licenses of the Cancer Immunology group IL-2v immunocytokines | ICIs |lung cancer | LTK2 | GEMM | tumor xenografts | co-culture | IHC | intratracheal | SPECT/µCT | animal licenses

Ludwig Cancer Research | Jan 2007 - Jan 2011

Maître Assistant / Lab Manager

▪ characterization of CD8 T cell responses after therapeutic vaccination of melanoma patients with antigenic Melan-A/MART-1 peptides ▪ prospective phase I clinical trial from the group of Prof. P. Romero, Prof. D. Speiser and Dr. N. Rufer ▪ mentoring of students and technical staff ▪ collaboration with the Molecular Modelling group of Prof. O. Michielin TCR | tetramers | flow cytometry | sequencing | RT-PCR | microarray | single cells | cell sorting | peptides | PBMCs | T cell cloning | CTL | ELISpot | lentivirus

Université Claude Bernard Lyon 1 | May 2007 - Sep 2007

Visiting Scientist

▪ initiation of a national project on the transduction of human DCs with adenovirus and enhanced presentation of HIV-1 epitopes; applications to the potentiation of an anti-HIV-1 response ▪ continuation of a collaborative project started in Jan. 2006 with the Laboratory of Virology & Viral Pathogenesis (Prof. P. Boulanger) HIV | adenovirus | dendritic cells | molecular biology | grant

Université de Strasbourg | Oct 2003 - May 2007

PhD candidate

▪ development of innovative functional CD40L mimetics based on C3- symmetric peptide scaffolds, at the interface of chemistry and biology, and applications to cancer vaccines and immunotherapy ▪ lab manager in the Immunologie et Chimie Thérapeutiques (Prof. S. Müller), Institut de Biologie Moléculaire et Cellulaire (IBMC) ▪ mentoring of students and technical staff apoptosis | confocal microscopy | SDS-PAGE | Western blot | 2D gel- electrophoresis | ELISA | hybridoma | chromatography | surface plasmon resonance | dynamic light scattering | organic chemistry | mass spectroscopy

Université de Strasbourg | Jan 2004 - Jan 2007

Teaching Assistance in Immunology

▪ course assistant in immunology “travaux pratiques” for B.Sc. biochemistry, Université Strasbourg I ▪ teaching assistant in immunobiology “travaux dirigés” for first college degree in biology, Université Strasbourg I immunology | teaching

CNRS - Centre national de la recherche scientifique | Jan 2004 - Jan 2006

IT support

▪ IT help to all my colleagues: installation of scientific software, Windows, workshops, hardware fix (with headache), network troubleshooting, Windowd again ▪ deployment and optimization of new hardware (computers and instruments) Windows server | peripherals | network | installation | configuration | maintenance | troubleshooting

My Education

Take a look at my formal education

Ph.D., ImmunologyUniversité de Strasbourg | 2007
Master Degree, Health Biology/BiochemistryUniversité de Montpellier | 2003
Baccalauréat Scientifique, Spécialité Mathématiques Lycée Emmanuel d'Alzon, Nîmes | 1998

About Me

Sébastien Wieckowski

Highly accomplished immunologist with a PhD, specializing in immuno-oncology and cancer vaccine development for over 15 years in the biotechnology sector. Now data analyst biotech/pharma freelance.

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