After all of the hard work of acquiring data and getting them into a form you can work with, you ultimately want to make clear, succinct conclusions from them. This crucial last step of a data analysis pipeline hinges on the principles of statistical inference. In this course, you will start building the foundation you need to think statistically, speak the language of your data, and understand what your data is telling you. The foundations of statistical thinking took decades to build, but can be grasped much faster today with the help of computers. With the power of Python-based tools, you will rapidly get up-to-speed and begin thinking statistically by the end of this course.

Build the foundation you need to think statistically and to speak the language of your data.

Statistical Thinking in Python (Part 1)

After completing Statistical Thinking in Python (Part 1), you have the probabilistic mindset and foundational hacker stats skills to dive into data sets and extract useful information from them. In this course, you will do just that, expanding and honing your hacker stats toolbox to perform the two key tasks in statistical inference, parameter estimation and hypothesis testing. You will work with real data sets as you learn, culminating with analysis of measurements of the beaks of the Darwin's famous finches. You will emerge from this course with new knowledge and lots of practice under your belt, ready to attack your own inference problems out in the world.

Learn to perform the two key tasks in statistical inference: parameter estimation and hypothesis testing.

Statistical Thinking in Python (Part 2)

Machine learning is the field that teaches machines and computers to learn from existing data to make predictions on new data: Will a tumor be benign or malignant? Which of your customers will take their business elsewhere? Is a particular email spam? In this course, you'll learn how to use Python to perform supervised learning, an essential component of machine learning. You'll learn how to build predictive models, tune their parameters, and determine how well they will perform with unseen data—all while using real world datasets. You'll be using scikit-learn, one of the most popular and user-friendly machine learning libraries for Python.

Learn how to build and tune predictive models and evaluate how well they'll perform on unseen data.

Supervised Learning with scikit-learn

Mastery requires practice. Having completed Statistical Thinking I and II, you developed your probabilistic mindset and the hacker stats skills to extract actionable insights from your data. Your foundation is in place, and now it is time practice your craft.

In this course, you will apply your statistical thinking skills, exploratory data analysis, parameter estimation, and hypothesis testing, to two new real-world data sets. First, you will explore data from the 2013 and 2015 FINA World Aquatics Championships, where you will quantify the relative speeds and variability among swimmers. You will then perform a statistical analysis to assess the "current controversy" of the 2013 Worlds in which swimmers claimed that a slight current in the pool was affecting result. Second, you will study the frequency and magnitudes of earthquakes around the world. Finally, you will analyze the changes in seismicity in the US state of Oklahoma after the practice of high pressure waste water injection at oil extraction sites became commonplace in the last decade. As you work with these data sets, you will take vital steps toward mastery as you cement your existing knowledge and broaden your abilities to use statistics and Python to make sense of your data.

Take vital steps towards mastery as you apply your statistical thinking skills to real-world data sets and extract actionable insights from them.

Case Studies in Statistical Thinking

One of the primary goals of any scientist is to find patterns in data and build models to describe, predict, and extract insight from those patterns. The most fundamental of these patterns is a linear relationship between two variables. This course provides an introduction to exploring, quantifying, and modeling linear relationships in data, by demonstrating techniques such as least-squares, linear regression, estimatation, and bootstrap resampling. Here you will apply the most powerful modeling tools in the python data science ecosystem, including scipy, statsmodels, and scikit-learn, to build and evaluate linear models. By exploring the concepts and applications of linear models with python, this course serves as both a practical introduction to modeling, and as a foundation for learning more advanced modeling techniques and tools in statistics and machine learning.

Explore the concepts and applications of linear models with python and build models to describe, predict, and extract insight from data patterns.

Learn how to explore, quantify, and model linear relationships in data, by using techniques like least-squares, linear regression, estimation and more.

Introduction to Linear Modeling in Python

RNA-Seq is an exciting next-generation sequencing method used for identifying genes and pathways underlying particular diseases or conditions. As high-throughput sequencing becomes more affordable and accessible to a wider community of researchers, the knowledge to analyze this data is becoming an increasingly valuable skill. Join us in learning about the RNA-Seq workflow and discovering how to identify which genes and biological processes may be important for your condition of interest! We will start the course with a brief overview of the RNA-Seq workflow with an emphasis on differential expression (DE) analysis. Starting with the counts for each gene, the course will cover how to prepare data for DE analysis, assess the quality of the count data, and identify outliers and detect major sources of variation in the data. The DESeq2 R package will be used to model the count data using a negative binomial model and test for differentially expressed genes. Visualization of the results with heatmaps and volcano plots will be performed and the significant differentially expressed genes will be identified and saved.

Use RNA-Seq differential expression analysis to identify genes likely to be important for different diseases or conditions.

RNA-Seq with Bioconductor in R

Imagine being able to handle data where the response variable is either binary, count, or approximately normal, all under one single framework. Well, you don't have to imagine. Enter the Generalized Linear Models in Python course! In this course you will extend your regression toolbox with the logistic and Poisson models, by learning how to fit, understand, assess model performance and finally use the model to make predictions on new data. You will practice using data from real world studies such the largest population poisoning in world's history, nesting of horseshoe crabs and counting the bike crossings on the bridges in New York City.

Extend your regression toolbox with the logistic and Poisson models and learn to train, understand, and validate them, as well as to make predictions.

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