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How AI Agents Will Work While You Sleep with Ruslan Salakhutdinov, Professor at Carnegie Mellon

Richie and Russ explore the most exciting use cases of AI agents today, long horizon tasks, the credit assignment problem, multi-agent systems, eliable human-in-the-loop workflows, agent safety and guardrails, and much more.
· 58 min lire
Ruslan Salakhutdinov

Invité

Ruslan Salakhutdinov

Ruslan Salakhutdinov is a UPMC Professor of Computer Science at Carnegie Mellon University and one of Geoffrey Hinton's former PhD students. He has previously served as Director of AI Research at Apple and VP of Research in Generative AI at Meta. His research focuses on deep learning, reasoning, and AI agents.

Richie Cotton

Hôte

Richie Cotton

Richie helps individuals and organizations get better at using data and AI. He's been a data scientist since before it was called data science, and has written two books and created many DataCamp courses on the subject. He is a host of the DataFramed podcast, and runs DataCamp's webinar program.

Chat with AI Richie about every episode of DataFramed - all data champs welcome!

Key Quotes

I would never use any of the agent systems to book me a flight. I can ask any agent system to find flights from Pittsburgh to San Francisco next Tuesday and book one for me. I would never do that. Even if it's 80% correct, there's at least a 20% gap where it'll go and do something crazy. The fact of the matter is they would have to be almost 99.99% accurate for me to fully trust them.

Manipulating objects turns out to be such a difficult thing — especially dexterous manipulations, like when you have two hands and the ability to grab a cup and move it around. I can train the model to do it for this cup, but being able to do it for any cup turns out to be extremely difficult. Whoever cracks this particular manipulation problem, I think it'll be the next trillion-dollar company.

Key Takeaways

  1. Multi-agent orchestration is replacing monolithic agents for complex work. A frontier model handles planning while smaller, cheaper, sometimes-local agents execute the subtasks and report back — so teams designing internal agent stacks should be thinking about communication protocols and task routing, not just picking the biggest model on the leaderboard.

  2. Hardwire guardrails for destructive actions — don't train them. Deleting databases, charging credit cards, sending emails — irreversible operations should be sandboxed at the system layer, not learned through RLHF. Treat alignment as a soft research problem and irreversibility as a hard engineering problem.

  3. Robotic manipulation is the trillion-dollar frontier — but factories come first. General home robots are years away because every home is a different mess. The realistic short-term wins for physical AI are constrained environments: factories, warehouses, mapped self-driving routes, and eldercare assistance for people with limited mobility.

Transcription

Richie Cotton: Hi Russ. Welcome to the show. 

Russ Salakhutdinov: Thank you for having me. 

Richie Cotton: Yeah, great to have you here. I'd like to talk about agents to begin with. So first of all, what is the most exciting use case of AI agents that you've seen? 

Russ Salakhutdinov: So I think over the last, couple of years we've seen really big improvement of agent systems in coding.

I think that's one extremely. Important use case. And we are seeing this right now, just even over the last few months. Genetic systems from Anthropic, Code. We are using it here at CMU quite extensively. It's been remarkable. I'm also seeing some of the genetic systems becoming more and more useful what we call computer usage agents.

So these agent systems that, can help you with computer tasks. For example, finding some information online or filling forms for you, or, because these agent systems can. Probably do it better than humans can. That's the area that we also had seen you are looking at quite extensively in general, any system that can be automated or can be autonomous in solving tasks.

I think, you'd consider to be a good agent system. 

Richie Cotton: Absolutely. So agents seem to be the hottest story of 2026. I feel like I've been talking about 'em for months now, but yeah, having that increased level of autonomy is is amazing. It's like how we get things done faster. So I'm curious as to where the limits are, like how.

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